PROTECTIVE EFFECT OF SANSHEN WEIXIN CAPSULA ON CARDIAC FUNCTION OF RATS WITH HEART FAILURE FOLLOWING MYOCARDIAL INFARCTION

The aim of this study was to prepare and characterize puerarin nanosuspension to enhance the dissolution rate and oral bioavailability of this drug. Nanosuspension was prepared by the anti-solvent precipitation method. The particle size and zeta potential of nanosuspension were 195 nm (± 8 nm) and -12.5 mV (± 1.2 mV), respectively. The morphology of nanosuspension was found to be flaky-shaped by scanning electron microscopy (SEM) observation. The X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC) analysis confirmed that the nanosuspension was in the amorphous state. The flow-through cell was considered to be the most robust dissolution method for the nanoparticulate system. The dissolution rate of nanosuspension was significantly increased by reducing the particle size. The dissolution testing in water showed that the nanosuspension exhibited significantly a higher dissolution rate with 71.9% drug dissolved in 5 min as compared to the raw puerarin (15.2%).