MOLECULAR CHARACTERISATION AND DISSOLUTION PROFILE OF SOLID FORMULATIONS OF METFORMIN
Journal: Journal of Biopharmaceutics Sciences (JBS)
Author: K. Anand Solomon, J. Satyanarayana Reddy, B.N.Vedhahari
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
In the present study, three novel multi-component salts of the anti-diabetic drug metformin, one with antiinflammatory drug diclofenac and two with pharmaceutically active co-crystal formers i.e., succinic acid and fumaric acid have been synthesized. The new solid phases have been preliminarily characterized by differential scanning calorimetry (DSC) and FT-IR analyses. The Single Crystal X-ray Diffraction (SCXRD) reveals the proton transfer from carboxylic acid group of co-formers to guanidine moiety metformin confirming the formation of new molecular salts. The molecular packing of all the salts is mainly supported by N−H···O– and N−H···N and hydrogen bonding interactions. The diclofenac salt of metformin interestingly shows a dissolution profile in a sustained release manner.